Mathis' ace launches him to lead at Travelers

David Mathis watches his drive on the first hole during the first round of the Travelers Championship golf tournament in Cromwell, Conn., Thursday, June 21, 2012. Mathis finished in the lead at 6-under-par. (AP Photo/Fred Beckham)

David Mathis watches his drive on the first hole during the first round of the Travelers Championship golf tournament in Cromwell, Conn., Thursday, June 21, 2012. Mathis finished in the lead at 6-under-par. (AP Photo/Fred Beckham)

Bubba Watson watches his drive on the 18th hole during the first round of the Travelers Championship golf tournament in Cromwell, Conn., Thursday, June 21, 2012. Watson finished his round with a 4-under par 66. (AP Photo/Fred Beckham)

Frederik Jacobson, of Sweden, watches his chip-shot on the 15th hole during the first round of the Travelers Championship golf tournament in Cromwell, Conn., Thursday, June 21, 2012. Jacobson finished with a 5-under par 65. (AP Photo/Fred Beckham)

CROMWELL, Conn. (AP) ? David Mathis had a hole-in-one and shot a 6-under 64 on Thursday to take a one-stroke lead after the first round of the Travelers Championship.

The 38-year-old Mathis, who missed the cut last week in the U.S. Open, began play on the back nine, making a birdie on 10 before holing out from 158 yards shot on the par-3 11th hole. He was 6 under after six holes.

Nathan Green, Will Claxton and defending champion Fredrik Jacobson shot 65 on a day that saw temperatures soar into the upper 90s.

U.S. Open champion Webb Simpson and Masters winner Bubba Watson played together and finished in a group of 10 at 66. The third member of the threesome, PGA champion Keegan Bradley, shot a 68.

"We were relaxed all day," Simpson said. "Bubba is my Presidents Cup partner. We always laugh together. And I've played a lot of golf with Keegan this year. He's a good friend. We had a lot of fun feeding off each other, and luckily, we all played well."

Mathis' ace was the shot of the day. He said he was just trying to cut a 9-iron close to the pin and it hit exactly where he aimed, bounced right and into the hole.

"It was an awesome start," he said. "I was hitting a lot of great shots (later), and I guess it felt like a lull compared to how I started."

Green teed off at 6:50 a.m., well before heat and humidity set in, setting the early mark with a 65. Claxton opened his round with a birdie and an eagle, but finished with a bogey on 18.

"To start out birdie-eagle, that's huge," Claxton said. "I obviously had the driver going. I drove the ball well today. It wasn't as difficult as I thought it might be."

Jacobson, who picked up his only PGA Tour win at the event a year ago, spent much of the day atop the leaderboard before a double bogey on 16 dropped him to 5 under and into a three-way tie for second.

"I knew it was going to be challenging in this heat, and if you start to miss a few shots, it can get to you," he said. "So I was just happy to get through this day."

One of Jacobson's playing partner's, former Masters champion Zach Johnson, also had a tough finish. He was 3 under when he hit a drive over the green at 15. He made a 6 there and a seven on the par-4 17th, where he tried to putt from the fringe, and needed three more after making it to the green.

A gallery of fans five and six deep greeted Simpson, Watson, and Bradley on the first tee, and many followed them throughout what all three said was a relaxed round.

"Any time you can play with those guys, it's fun," Watson said. "We learn from each other. We watch each other. We're making some jokes out there. We were having a good time. It was good."

But it wasn't fun for everybody. Former UCLA star Patrick Cantlay made his professional debut with a 75 on the same course where he made headlines last year with a second-round 60 as a 19-year-old amateur.

"I started off poorly with a couple of doubles and couple weird things happened, and it just added up to a bad round," Cantlay said.

Associated Press

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Boehner takes hard line on Holder contempt vote

The House Oversight and Government Reform Committee, led by Chairman Darrell Issa, R-Calif., considers whether to hold Attorney General Eric Holder in contempt of Congress, on Capitol Hill in Washington, Wednesday, June 20, 2012. In a showdown with President Barack Obama?s administration, House Republicans are pressing for more Justice Department documents on the flawed gun-smuggling probe known as Operation Fast and Furious that resulted in hundreds of guns illicitly purchased in Arizona gun shops winding up in the hands of Mexican drug cartels. (AP Photo/J. Scott Applewhite)

The House Oversight and Government Reform Committee, led by Chairman Darrell Issa, R-Calif., considers whether to hold Attorney General Eric Holder in contempt of Congress, on Capitol Hill in Washington, Wednesday, June 20, 2012. In a showdown with President Barack Obama?s administration, House Republicans are pressing for more Justice Department documents on the flawed gun-smuggling probe known as Operation Fast and Furious that resulted in hundreds of guns illicitly purchased in Arizona gun shops winding up in the hands of Mexican drug cartels. (AP Photo/J. Scott Applewhite)

Rep. Darrell Issa, R-Calif., right, chairman of the House Oversight and Government Reform Committee, manages a series of amendments as they consider a vote to hold Attorney General Eric Holder in contempt of Congress, on Capitol Hill in Washington, Wednesday, June 20, 2012. Rep. Elijah Cummings, D-Md., the ranking member, watches from left. In a showdown with President Barack Obama's administration, House Republicans had pressed for more Justice Department documents on the flawed gun-smuggling probe known as Operation Fast and Furious that resulted in hundreds of guns illicitly purchased in Arizona gun shops winding up in the hands of Mexican drug cartels. (AP Photo/J. Scott Applewhite)

Rep. Dennis Kucinich, D-Ohio, left, confers with Rep. Elijah Cummings, D-Md., right, as the House Oversight and Government Reform Committee considers a vote to hold Attorney General Eric Holder in contempt of Congress, on Capitol Hill in Washington, Wednesday, June 20, 2012. (AP Photo/J. Scott Applewhite)

WASHINGTON (AP) ? Speaker John Boehner demanded Thursday that the Obama administration give in and turn over documents related to a botched gun-tracking operation, insisting that's the only way to stop a House vote to hold the attorney general in contempt.

Boehner took a hard line against the Obama administration and Attorney General Eric Holder despite a willingness by House Republicans and Holder to negotiate a settlement before the matter becomes a constitutional crisis. The president has invoked executive privilege, a legal principle used to avoid disclosure of internal presidential documents.

While a confrontation between the legislative and executive branches of government would be an academic dispute to most voters, Boehner on Thursday injected a human element into the dispute over documents related to Operation Fast and Furious. He said the family of slain border agent Brian Terry deserved answers about the guns that killed him.

Two guns that were allowed to "walk" from Arizona to Mexico in the failed effort to track weapons were found near Terry after he was killed.

"The Terry family deserves answers about why their son was killed as a result of an operation run by the United States government," Boehner told his weekly news conference.

During the year and a half investigation by the House Oversight and Government Reform Committee, the Justice Department turned over 7,600 documents about details of Operation Fast and Furious. But because the department initially denied and then admitted it used a risky investigative technique known as "gun-walking," the committee has turned its attention to how the Justice Department responded to the investigation. The additional documents it seeks are about that topic.

Agents of the U.S. Bureau of Alcohol, Tobacco, Firearms and Explosives in Arizona abandoned the agency's usual practice of intercepting all weapons they believed to be illicitly purchased. Instead, the goal of gun-walking was to track such weapons to high-level arms traffickers who had long eluded prosecution and to dismantle their networks.

Gun-walking has long been barred by Justice Department policy, but federal agents in Arizona experimented with it in at least two investigations during the George W. Bush administration before Fast and Furious. These experiments came as the department was under widespread criticism that the old policy of arresting every suspected low-level "straw purchaser" was still allowing tens of thousands of guns to reach Mexico. A straw purchaser is an illicit buyer of guns for others.

The agents in Arizona lost track of several hundred weapons in Operation Fast and Furious.

Boehner renewed his allegation that President Barack Obama's decision to assert executive privilege to withhold the documents "is an admission the White House officials were involved in the decision that misled the Congress and covered up the truth." In fact, historically, several presidents have invoked executive privilege over Cabinet department documents that did not directly involve White House officials.

House Democrats gave no ground. House Minority Leader Nancy Pelosi of California accused Republicans of pursuing Holder to retaliate against his effort to stop suppression of voters in the upcoming elections. "I'm telling you, this is connected," she told reporters.

Holder, in Copenhagen, Denmark, for meetings with European Union officials, said the administration had given the committee a proposal to negotiate an end to the conflict.

"I think the possibility still exists that it can happen in that way," Holder said. "The proposal that we have made is still there. The House, I think, the House leadership, has to consider now what they will do, so we'll see how it works out."

But he called the contempt vote "unwarranted, unnecessary and unprecedented."

White House press secretary Jay Carney said there was "absolutely" no cover-up on the Fast and Furious controversy. He said executive privilege was asserted only on internal deliberations and "that is separate from trying to find out the truth about this operation."

House Oversight Committee officials who would conduct any negotiations on behalf of Chairman Darrell Issa, R-Calif., said they are looking for at least some additional documents ? plus some "signs of good faith."

The latter could include substantive responses to future committee requests for documents; reforming the approval process for wiretap applications; acknowledging mistakes in misleading Congress about Fast and Furious; taking whistle-blowers seriously; and producing a log of documents to be turned over, according to the officials, who spoke only on condition of anonymity because they weren't authorized to discuss the issue by name. Committee officials said the department only gave cursory scrutiny to wiretap applications against Fast and Furious targets.

Democrats contended that the 23-17 party-line contempt vote in committee Wednesday was just political theater. The committee's top Democrat, Rep. Elijah Cummings of Maryland, called the vote "an extreme, virtually unprecedented action based on election-year politics rather than fact."

Holder offered to give lawmakers a briefing on the withheld documents but insisted that this action satisfy Issa's subpoena for the records and negate the need for a contempt vote. Issa rejected the offer, saying it was an attempt to force an end to the committee's investigation.

Boehner on Thursday rejected Holder's approach.

"The negotiation that was proposed by the attorney general is, we should accept some documents of his choosing and, as a result of him turning over some documents of his choosing, that we would never ever pursue contempt," Boehner said. "Now this is not hardly a rational basis for a negotiation, nor is it a reasonable attempt at turning over the documents we've been asking for."

Associated Press

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Matt Groening ends "Life in Hell" after 30 years

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92% Headhunters

Do you ever tire of hearing that a Hollywood remake is in the pipeline, when the ink has hardly dried on the original script? Like "The Girl With The Dragon Tattoo", "Cell 211" and "Let The Right One In" before it, this is another that has had the green light for an English language version. It's easy to see why there would be interest in this as it's an exceptionally good thriller. I just don't see why it's necessary to have it redone. Roger Brown (Aksel Hennie) is a high-flying businessman who works as a headhunter. He scouts potential applicants for executive jobs. While interviewing them, he learns very useful information that leads him to his second source of income: a sideline in executing valuable art robberies. His extravagant and expensive lifestyle can't be funded by his headhunting job alone. One particular interviewee is Clas Greve (Nicolaj Coster-Waldau). He has all the credentials for a post that Brown needs to fill but he also has just inherited a piece of art that will cure all of Brown's financial woes - if he can just get his hands on it. As it turns out though, this art theft is not as simple as his previous ones and Greve is not as buttoned up as he makes out. As this film opens we are introduced to unlikely leading actor Aksel Hennie who has an appearance that resembles the love child of Christopher Walken and Steve Buscemi. He's not your average leading man and his character is not that appealing either. He's a self-centred weasel of a man that seems to lack any morals but you know that things are, not entirely, going to go to plan for this scheming, double-crossing thief and that's exactly what captures your attention and provides the hook in this adaptation of Norwegian writer Jo Nesbo's novel. Director Morten Tyldum is wise enough to play his cards when he needs them and wrings out the suspense, masterfully, at every turn. He mounts the tension slowly before staging one gripping scene after another. The unpredictability of the spiralling plot delivers genuine excitement, helped immeasurably by natural characters and performers. Hennie in particular, is absolutely brilliant and will no doubt become a household name after this (apparently he already is, in his native Norway). Kudos to screenwriters Lars Gudmstead and Ulf Ryberg. It's their tight, deliberately paced and unpredictable script that keeps you guessing and shows a good level of intelligence. Admittedly, I haven't read the novel but if I were author Jo Nesbo, I'd be very proud of the job that has been done here. When the headhunter becomes the headhunted, this film grips like a vice and refuses to let go. I've seen quite a few film's from Scandinavia over recent years and have been very impressed with the high standard they are delivering. This is no exception and a thriller that will definitely compete with the best of the year.

June 12, 2012

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Carcinogens linked to cancer stem cells, but spinach can help

ScienceDaily (June 20, 2012) ? Researchers at Oregon State University have for the first time traced the actions of a known carcinogen in cooked meat to its complex biological effects on microRNA and cancer stem cells.

The findings are part of a growing awareness of the role of epigenetics in cancer, or the ways in which gene expression and cell behavior can be changed even though DNA sequence information is unaltered.

The scientists also found that consumption of spinach can partially offset the damaging effects of the carcinogen. In tests with laboratory animals, it cut the incidence of colon tumors almost in half, from 58 percent to 32 percent.

The research at OSU's Linus Pauling Institute was recently reported in the journal Molecular Nutrition and Food Research, in work supported by the National Institutes of Health.

"Cancer development is a complex, multi-step process, with damaged cells arising through various means," said Mansi Parasramka, a postdoctoral scholar with LPI. "This study showed that alterations of microRNAs affect cancer stem cell markers in colon cancer formation.

"MicroRNAs are very small factors that do very big things in cells," she said.

Traditionally, cancer was thought to be caused by changes in DNA sequence, or mutations, that allowed for uncontrolled cell growth. That's still true. However, there's also increasing interest in the role played by epigenetics, in which such factors as diet, environmental toxins, and lifestyle affect the expression of genes -- not just in cancer, but also cardiovascular disease, diabetes, and neurological disorders.

Included in this epigenetic equation is the formation of microRNAs -- once thought to be "junk DNA" -- which researchers were at a loss to understand. It's now known that they influence which areas of DNA get expressed or silenced.

There are hundreds of microRNAs, and the OSU scientists monitored 679 in their experiments. When they don't work right, bad things can happen, including abnormal gene expression leading to cancer.

"Recent research is showing that microRNAs are one of the key epigenetic mechanisms regulating cellular functions in normal and diseased tissues," said Rod Dashwood, the Helen P. Rumbel Professor for Cancer Prevention and director of LPI's Cancer Chemoprotection Program.

"But unlike mutations which are permanent genetic changes in DNA," he said, "the good news about epigenetics and microRNA alterations is that we may be able to restore normal cell function, via diet and healthy life style choices, or even drug treatments."

Epigenetics essentially makes every person biologically unique, Dashwood said, a product of both their genetics and their environment. That includes even identical twins.

The findings of the new study should lead to advances in understanding microRNAs, their effects on cancer stem cells, and the regulatory processes disrupted in disease development, the OSU scientists said. This might lead one day to tailored or "patient specific" therapies for cancer, Dashwood said.

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The above story is reprinted from materials provided by Oregon State University.

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Journal Reference:

1. Mansi A. Parasramka, W. Mohaiza Dashwood, Rong Wang, Amir Abdelli, George S. Bailey, David E. Williams, Emily Ho, Roderick H. Dashwood. MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Molecular Nutrition & Food Research, 2012; DOI: 10.1002/mnfr.201200117

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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News: Sony Details the Advantages of Vita and PS3 Connectivity

New play controls

Multiple processors

Now that Nintendo has officially revealed the Wii U to the world, all three platform holders are jumping on board dual-screen technology. During its E3 press conference, Microsoft announced Smart Glass ? a feature that will allow players to interact with the Xbox 360 using a tablet computer. Meanwhile, Sony has focused on the interaction between PS3 and Vita.

While this functionality didn?t exactly headline the company?s E3 line-up, the platform holder was running a rather interesting demo of LittleBigPlanet 2 being played with Vita controls in a shadowy corner of its booth.

In that demo, the game was able to take advantage of both the processing power of the PlayStation Vita and the PlayStation 3 ? something Sony executive Scott Rohde believes is an advantage over the Wii U.

Speaking with GamesIndustry International, he said:

That Wii U tablet doesn't have a processor in it, so it's got to be fuelled by that box sitting under your TV.

We can do some pretty special things that you'll start to see on the [E3] floor this year and you'll see more over the upcoming months about what you can do when you actually have a processor in the thing that's in your hand as well.

Of course, the big caveat that Rohde?s not addressing is that ? unlike the Wii U gamepad ? the Vita is an expensive unit on its own. For significant resources to be put into Vita to PS3 cross-controller connectivity, developers will need to ensure that a substantial number of consumers own both devices, and that?s unlikely.

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26 killed in clashes in southeast Turkey

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